Born on December 31, 1820, in Cootehill, County Cavan, Ireland, Mary Anne Madden began contributing poems to the London periodical La Belle AssemblÄe when she was eighteen. In 1844 she came to the United States and settled in New York City. In November 1846 she married James Sadlier, co-owner of a publishing house specializing in Catholic literature. Until 1860 they lived in Montreal, where the firm had a branch. From there she contributed stories, essays, and translations to such periodicals as the Boston Pilot, the New York Tablet, The American Celt, and The Literary Garland.
She was best known for her novels, most of which appeared in serial form in Catholic newspapers before being published in book form. Among them were The Red Hand of Ulster, 1850, Alice Riordan, 1851, New Lights; or, Life in Galway, 1855, The Blakes and the Flanagans, 1855, Willie Burke, 1856(?), The Confederate Chieftains, 1860, Bessy Conway, 1862, The Fate of Father Sheehy, 1863, Con O╒Regan, 1864, Eleanor Preston, 1865 (?), Aunt Honor╒s Keepsake, 1866, Confessions of an Apostate, 1868, MacCarthy More, 1868, and Maureen Dhu, 1870; they numbered more than 60 in all.
From 1860 Sadlier lived again in New York City, where she became a noted figure in conservative Catholic circles. Her writings urged her readers to retain pride in their background and their ancestral faith while reconciling themselves to the customs and manners of their new land. Later works included Catechism of Sacred History and Doctrine, in collaboration with Mother Angela Gillespie, 1864, Purgatory: Doctrinal, Historical, and Poetical, 1886, and Stories of the Promises, with her daughter, Anna T. Sadlier, 1895. She also edited Poems of D╒Arcy McGee, 1869, and in 1885 published a translation of Matthieu Orsini╒s Life of the Blessed Virgin, Mother of God. In 1895 she was awarded the Laetare Medal by the University of Notre Dame. From the 1880s she lived again in Montreal, and she died there on April 5, 1903.
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